The human genome is a large DNA molecule composed by thousands of RNAs that regulates several metabolic pathways and participates in distinct cellular and molecular phenotypes. Independently of the classes they belongs to, most of transcribed RNA molecules undergo to a pos-transcriptional regulation called splicing. Briefly, splicing of RNA involves several steps to process primary messenger RNA molecules (pre-mRNA) to generate mature messenger RNAs (mRNA) (Figure 1). During each step of pre-mRNA processing, several so called small nuclear ribonucleoproteins (snRNAs) are combine with unmodified pre-mRNA and various other proteins to form a spliceosome. Thus, spliceosome regulates how pre-mRNA transcripts are spliced to generated a specific splicing isoform of a gene.
Figure 1 – Schematic overview of the human splicing reaction, the complete cycle through all stages of the spliceosome, and a list of genes involved in the process.
Publications
If you use Atlas of Curated Splicing Regulators in Humans in your work, please cite the following manuscript:
Rodrigues KS, Petroski LP, Utumi PH, Ferrasa A, Herai RH. IARA: a complete and curated atlas of the biogenesis of spliceosome machinery during RNA splicing. Life Sci Alliance. 2023 Jan 6;6(3):e202201593. doi: 10.26508/lsa.202201593. PMID: 36609432; PMCID: PMC9834665.